Multiscale whole-system modeling of bioreactors
2020-2022
Dr. Kahan is leading an international consortium of researchers using computational modeling to predict the efficiency of novel bioreactor designs and technologies at scale.
PRODUCTION PLATFORM: Cultivated
TECHNOLOGY SECTOR: Bioprocess design
![Computational modeling 1 Gfi's competitive research grants program badge, featuring a whole cut of meat within a magnifying glass representing research](png/competitive-research-grants-program-badge.png)
Project aims
This project aims to design multiscale whole-system models of several novel bioreactor technologies while developing quantitative efficiency characterizations of these new designs. It will simulate these models both to validate their accuracy against small bioreactors and to predict efficiencies of these bioreactors at greater scale.
This work will accelerate understanding and refinement of bioreactor designs and could ultimately reduce the cost of cultivated meat production via improved bioreactor efficiency.
Principal researcher
![Computational modeling 2 Gfi grantee dr. Simon kahan, founder, cultivated meat modeling consortium](jpg/simon-kahan-scaled-1-1024x1024.jpg)
Dr. Simon Kahan
Founder, Cultivated Meat Modeling Consortium
Dr. Kahan holds 30 years’ experience in high-performance computing. He leads a team of experts in both bioreactor design and fluid-flow and cell-system modeling. He founded the Cultivated Meat Modeling Consortium, an international and interdisciplinary coalition, to advance cultivated meat through computational modeling.
![Computational modeling 3 Abstract representation of computational modeling for cultured meat](jpg/arif-wahid-266541-unsplash-1-1-603x757.jpg)
Cultivated Meat Modeling Consortium
Check out the latest work from Dr. Kahan and the Cultivated Meat Modeling Consortium, and explore a proof-of-concept demo simulation at their website.
View related grant projects
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Integrating sensors into bioreactors
GFI grantees Dr. Ivana Gadjanski and Dr. Vasa Radonic are integrating sensors into bioreactors for cultivated meat production.
![Computational modeling 5 Pattern of cells, representing cell culture for meat cultivation](jpg/shutterstock_102685253-435x297.jpg)
Co-culturing cells
GFI grantee Dr. Mariana Petronela Hanga is researching culturing different cell types at the same time.
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Designing cost-effective bioreactors
Learn about Dr. Marianne Ellis’s work at University of Bath to reduce the cost of bioreactors for cultivated meat production.
Explore research opportunities
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Cultivated
Scaffolds and structural approaches to optimize fat distribution and content in cultivated meat
The inclusion of fat and marbling in cultivated meat is likely to increase its flavor, texture, and consumer appeal. Structural approaches using edible microcarriers, hydrogels, and 3D bioprinting present promising…
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Cost-effective sterility controls for cultivated meat
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Plant-Based
Plant-based scaffolds to improve cultivated meat nutrition
A variety of plant-based scaffolds present the opportunity to combine the natural nutritional and structural benefits of plants with the taste and high protein of cultivated meat. Bacterial nanocellulose from…
![Computational modeling 11 A battered and fried cultured meat, a cultured chicken cutlet, plated with sauteed greens and mashed root vegetables | image courtesy of upside foods](jpg/cultivated-meat-header-603x757.jpg)
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The science of cultivated meat
Learn about the science of cultivated meat and the challenges that must be addressed for commercial production.